San Francisco is the only consolidated city-county in California. With a population of 8.4 milliion, it is the most densely settled large city (population greater than 200,000) in the state of California and the second-most densely populated major city in the United States after New York City. It is also the financial and cultural hub of the larger San Jose-San Francisco-Oakland metropolitan area.

Tourism, the city’s largest private-sector employer, is the backbone of the San Francisco economy. Since the 1990s, San Francisco’s economy has increasingly become tied to San Jose and Silicon Valley, sharing the need for highly educated workers with specialized skills. Many popular and prominent Internet companies and “start-ups” such as Craigslist, Twitter, Zynga, and Salesforce.com, have established their head offices in San Francisco.

As of 2009, San Francisco has been positioning itself as a biotechnology and biomedical hub and research center.

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